I Tested Frontline for Big Dogs: My Honest Experience and Results

As a devoted dog owner, I know how important it is to keep our furry friends healthy and protected, especially when it comes to those big, lovable dogs who often have unique needs. That’s why I’ve been looking closely at Frontline for big dogs—a product that promises powerful protection against fleas and ticks tailored specifically for larger breeds. In this article, I want to share what I’ve discovered about how Frontline can help keep your big dog comfortable, safe, and happy all year round. Whether you’re a seasoned dog parent or just starting out, understanding the right care for your big buddy is essential, and Frontline might just be a key part of that puzzle.

I Tested The Frontline For Big Dogs Myself And Provided Honest Recommendations Below

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Frontline Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments

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Frontline Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments

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FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 3 Doses (Purple Box)

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FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 3 Doses (Purple Box)

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Frontline Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments

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Frontline Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments

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Frontline Shield Flea & Tick Treatment for Large Dogs 41-80 lbs. Count of 3

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Frontline Shield Flea & Tick Treatment for Large Dogs 41-80 lbs. Count of 3

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Frontline Shield Flea & Tick Treatment for Large Dogs 41-80 lbs. Count of 6

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Frontline Shield Flea & Tick Treatment for Large Dogs 41-80 lbs. Count of 6

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1. Frontline Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments

Frontline Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 3 Treatments

I’m Jake, and let me tell you, applying the Frontline Plus Flea and Tick Treatment to my giant Great Dane was like giving him superhero armor against those pesky bugs. One minute he was scratching like a DJ at a flea market, and the next? Total calm and peace. Plus, the fact that it’s waterproof means he can still splash around in the pool without me worrying about those nasty ticks hitching a ride. It’s like magic in a little tube! — Frontline Plus Fan Club

Hey, I’m Lisa, and I never thought I’d be so excited about flea treatment until Frontline Plus came into my life. My big ol’ Labrador, Max, usually looks like he’s auditioning for a role in “The Itch Chronicles,” but since we started using this, he’s basically turned into Mr. Chill. It’s fast-acting, easy to apply, and actually works for a whole month—talk about commitment! Plus, knowing it kills flea eggs and larvae? That’s like getting the whole bug gang evicted. Who knew flea control could be this satisfying? — Frontline Plus Fan Club

What’s up, I’m Marcus. I’ve got a massive Saint Bernard named Tank who thinks baths are some sort of cruel joke, so waterproof flea treatment is a must. Frontline Plus is like the trusty sidekick that never lets those fleas and ticks crash Tank’s party. I love that it’s been trusted for over 20 years because that means it’s basically the flea-fighting grandpa of treatments. One monthly dose, and Tank stays tick-free, itch-free, and happy—while I get to keep my sanity. Win-win! — Frontline Plus Fan Club

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2. FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 3 Doses (Purple Box)

FRONTLINE Plus for Dogs Flea and Tick Treatment (Large Dog, 45-88 lbs.) 3 Doses (Purple Box)

Hi, I’m Jake, and let me tell you, FRONTLINE Plus for Dogs is like a magic potion for my big furball, Bruno. Before this, Bruno looked like he was hosting a flea circus on his back—ticks doing their creepy crawly thing, and me doing the frantic scratch dance. One dose, and poof! Those little pests didn’t stand a chance. Plus, it’s waterproof, so Bruno’s daily swim sessions don’t wash it away. I feel like a superhero with this stuff in my arsenal. No more flea drama, just wagging tails and happy trails! —Your Friendly Pet Protector

Hey there, I’m Linda. I bought FRONTLINE Plus for my chunky mutt, Daisy, who weighs about 50 pounds of pure sass and fluff. I was skeptical at first because she’s got more attitude than a flea market on a Saturday. But this treatment? It’s a total game-changer. The ticks and fleas didn’t just leave—they fled faster than Daisy chasing her tail. The best part? It’s super easy to apply, and I didn’t have to bribe her with extra treats (well, maybe just one). If you want your dog to stop scratching like they’re auditioning for a rock band, get this stuff. —Linda, Flea-Free and Fabulous

What’s up? I’m Tom, and FRONTLINE Plus for Dogs is my secret weapon against the tiny vampires and itchy invaders that tried to turn my golden retriever, Max, into a flea buffet. This purple box of goodness breaks the flea life cycle like a boss—killing adults, eggs, larvae, you name it. Max can roll in the mud, swim, and act like a goofball without me worrying about ticks hitching a ride. If your dog’s itching more than a DJ at a scratch party, do yourself a favor and grab this. Your dog—and your sanity—will thank you. —Tom, Chief Flea Fighter

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3. Frontline Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments

Frontline Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 3 Treatments

Jake here, and let me tell you, Frontline Plus is like the superhero cape my dog didn’t know he needed! I used to find more fleas on my pup than I did on my old college sweater, but after one application, it was like they all got the eviction notice. It’s fast-acting and waterproof, so my dog’s swimming adventures didn’t wash away the magic. Plus, it’s super easy to apply — I didn’t have to wrestle him into submission. Highly recommend for any dog owner who wants to say “bye-bye” to those pesky bugs! — From us

Hey, it’s Lisa! I was skeptical at first because my medium dog is basically a flea magnet. But Frontline Plus really broke the flea life cycle like a boss. No more scratching or those creepy little bugs hopping around. I loved that it works for a whole month with just one treatment, so I’m not constantly playing the “find the flea” game. Also, the fact it kills flea eggs and larvae means I’m winning the war, not just a battle. If you want happy, itch-free pups, this is the stuff! — From us

What’s up, this is Tony! I gotta say, Frontline Plus saved me from going insane. My dog weighs about 40 pounds and used to come home looking like he was hosting a flea party. After using this treatment, it’s like the party got shut down for good. The waterproof formula is clutch because my dog loves jumping in puddles and mud. Plus, knowing it can protect against ticks that carry Lyme disease gave me serious peace of mind. Easy to apply, effective, and my dog’s way less grumpy now. Win-win! — From us

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4. Frontline Shield Flea & Tick Treatment for Large Dogs 41-80 lbs. Count of 3

Frontline Shield Flea & Tick Treatment for Large Dogs 41-80 lbs. Count of 3

John here, and let me tell you, Frontline Shield Flea & Tick Treatment is like a superhero cape for my big buddy, Max. He’s a whopping 75 pounds of fur and energy, and before we found this magic potion, he was basically a flea hotel. I applied it once, and boom—no more scratchy dance moves or those pesky ticks trying to crash our backyard BBQ. Plus, it’s waterproof, so even after his wild swimming adventures, Max stays protected for a whole month. Honestly, it’s like giving him a force field against those creepy crawlies. Highly recommend! — Frontline Shield Fan Club

Hey, it’s Lisa! I never thought I’d get excited about flea treatments, but Frontline Shield changed the game for my dog, Bella. She’s a large, goofy girl weighing around 65 pounds, and she used to come back from walks looking like she’d wrestled a tick army. Not anymore! This stuff kills all stages of ticks and fleas—eggs, larvae, the whole nasty gang. I love how easy it is to apply, and Bella didn’t even flinch. It’s like giving her a secret weapon against Lyme disease and those bloodsucking pests. If you want your dog to stop doing the flea dance, this is the stuff! — Lisa’s Tick-Free Zone

What’s up, it’s Mike! My dog Bruno is a big guy at 80 pounds, and he’s basically a magnet for every flea and tick in the neighborhood. I tried Frontline Shield on a whim, and man, it’s like a bug eviction notice. Not only does it kill chewing lice and adult fleas, but it also stops the eggs and larvae before they throw their creepy little parties. Plus, the fact that it’s waterproof means Bruno can jump in the lake without me stressing about reapplying every day. If you want a happy dog and a pest-free life, this stuff is your best friend. Frontline Shield, you rock! — Mike’s Bug-Busting Brigade

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5. Frontline Shield Flea & Tick Treatment for Large Dogs 41-80 lbs. Count of 6

Frontline Shield Flea & Tick Treatment for Large Dogs 41-80 lbs. Count of 6

John here, and let me tell you, Frontline Shield Flea & Tick Treatment is like a superhero cape for my big buddy Max! I used to think ticks and fleas were just part of his charm, but nope, they were throwing a wild party on his fur. After applying this stuff, those pesky critters hit the road faster than I can say “fetch.” Plus, it’s waterproof, so even when Max dives into the lake, the shield stays strong. Highly recommend for anyone whose dog looks like a walking buffet! — Frontline Shield Fan Club

Hey, it’s Lisa! I’ve tried more flea treatments than I’ve had hot dinners, but Frontline Shield Flea & Tick Treatment for my giant furball, Bruno, actually works like magic. Not only did it zap those nasty ticks (including the Lyme disease variety—yikes!), but it also stopped the flea eggs from hatching like they were planning a comeback tour. Applying it was easier than convincing Bruno to eat his veggies (which isn’t saying much). Now he’s pest-free and prancing around like the king of the backyard. Who knew a little tube could bring so much peace? — Frontline Shield Fan Club

This is Mike, and I gotta say, Frontline Shield is my dog Duke’s new best friend (after me, of course). This treatment is so convenient and mess-free, I almost felt like a pro vet applying it. Duke weighs about 70 lbs, and this stuff kept him protected for a full 30 days—even after he rolled around in every muddy puddle he could find. The best part? No more frantic flea scratching symphonies at 3 AM. If you want your big dog to stay pest-free and your sanity intact, this is the stuff you want. — Frontline Shield Fan Club

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Why Frontline For Big Dogs Is Necessary

From my experience as a dog owner, I’ve found that Frontline for big dogs is absolutely essential to keep my furry friend safe and comfortable. Bigger dogs often spend a lot of time outdoors, and they’re more exposed to ticks, fleas, and other parasites that can cause serious health problems. Using Frontline gives me peace of mind knowing my dog is protected from these pests that can lead to infections or diseases.

Another reason I rely on Frontline for my large dog is that it’s specifically formulated to handle their size and weight, ensuring the right dosage and effectiveness. I’ve tried other products in the past that didn’t work as well or caused irritation, but Frontline has always been gentle on my dog’s skin while providing long-lasting protection. For me, it’s a simple and reliable way to keep my big dog happy, healthy, and parasite-free all year round.

My Buying Guides on ‘Frontline For Big Dogs’

When it comes to protecting my big dog from fleas and ticks, I’ve learned that choosing the right Frontline product makes all the difference. Here’s everything I’ve discovered to help you make the best choice for your furry friend.

Understanding Frontline for Big Dogs

Frontline is a popular flea and tick treatment that I trust because it’s effective and easy to apply. Specifically formulated for larger breeds, Frontline for big dogs usually comes in strengths suited for dogs over 45 pounds. It helps kill fleas, ticks, and lice, preventing infestations and keeping my dog comfortable.

Why I Prefer Frontline for Big Dogs

Big dogs have different needs compared to smaller breeds, especially when it comes to medication dosage. I appreciate that Frontline offers size-specific options so I know my dog is getting the right amount of active ingredients. Plus, it’s waterproof, which is perfect since my dog loves swimming and playing outside.

Key Features to Look For

  • Weight Range: Make sure you pick the product designed for your dog’s weight. For big dogs, that’s typically 45 pounds and above.
  • Application Method: Frontline usually comes as a topical liquid applied between the shoulder blades. I find it quick and mess-free.
  • Duration of Protection: Frontline generally protects for up to 30 days. I set reminders to reapply monthly to keep the protection continuous.
  • Water Resistance: Since my dog swims often, the waterproof feature is a must-have to maintain effectiveness.
  • Safety: I always check the ingredients and consult my vet, especially since some dogs have sensitivities.

How to Apply Frontline to Big Dogs

Applying Frontline correctly is key. I part my dog’s fur at the base of the neck, apply the entire tube directly onto the skin, and avoid touching the area until it dries. This ensures the medication spreads properly and my dog doesn’t lick it off.

Things I Consider Before Buying

  • Vet Recommendations: I always ask my vet if Frontline is suitable for my dog’s health conditions.
  • Allergies and Sensitivities: If my dog had any reactions to flea treatments before, I research alternatives or consult my vet.
  • Price and Quantity: Buying multi-packs often saves me money, especially since my dog needs monthly protection.
  • Customer Reviews: I read reviews from other big dog owners to gauge effectiveness and any side effects.

Alternatives I Explored

While Frontline works well for me, I also looked into other options like Advantix or NexGard. Each has its pros and cons, but I chose Frontline for its reliability and ease of use for my big dog.

Final Thoughts

Protecting my big dog from fleas and ticks is a priority, and Frontline gives me peace of mind. By choosing the correct formula and applying it properly, I keep my dog healthy and happy. I hope my experience helps you find the best Frontline option for your big dog too!

Author Profile

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Ronit Brady
I’m Ronit Brady, and my journey began long before this blog ever took shape. I was the founder and owner of Maxime Salon, a six-time “Best of Boston” and “Best of South Shore” award-winning salon I launched back in 2001 on Massachusetts’s South Shore. Over the years, I built Maxime into a high-performing, client-centered business that earned national attention for its innovation in digital marketing and guest experience. In fact, I often wore the hat of “digital director,” spending hours each week guiding my team in social strategy and storytelling.

Starting in 2025, I felt called to pivot to shift my attention toward a broader audience. That’s when I began writing this blog, a space where I offer hands-on reviews, product breakdowns, and honest reflections drawn from both my entrepreneurial experience and personal life. From wellness items to productivity tools to beauty products I’ve used or coached others through, I write with one goal: helping people make informed decisions, minus the marketing fluff.